I also use Spotlight. Under Leopard, it is so fast that it has bumped Quicksilver off my Mac. One hint for Spotlight, which is pretty well known, is to open System Preferences>Spotlight and drag rearrange the search order of the things that Spotlight searches.

I put Applications first, then Mail messages, then documents. This finds applications very, very quickly. It doesn't have the smart abbreviation learning of Quicksilver or Butler or Launchbar, but it works well enough and uses only the built in OSX tools.

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