It simply depends on your needs. In my case, I know that there will be one to many tiff-files which need to be ocr'ed. It's very simple to get a list of files with AppleScript:
tell application "Finder"
set myFolder to alias "Volumename:path:to:folder:"
set myList to every file of myFolder as alias list
end tell
You then have an array with all the files as alias. With a repeat or while or whatever kind of loop you can process the files.

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